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has reported that 1,000 mg of metformin twice a day improved the fasting plasma glucose level in only metformin-treated diabetes and the metabolite 1,5-anhydroglucitol (1,5-AG) was associated with glucose-lowering effect (Table 1

Pre-clinical studies highlighted the efficacy of small molecule mimetics of BDNF, such as deoxygedunin and N-acetyl-serotonin, against AD neuropathology (Jang et al., 2010a, 2010b

Identifiable triggers may include bacterial infections, excessive alcohol consumption, and relapse of chronic viral hepatitis, whereas non-identifiable triggers do not have any clinically identifiable cause (24, 25)

In this study, it was hypothesised that the strong afferent input to the brain from the stimulation of cold receptors in the skin during cold-water immersion could result in an anti-depressive effect